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Home > Our Doctors > Our Doctors > Department of Cardiology > Assistant Professor Chester Drum

Assistant Professor Chester Drum



Consultant, Department of Cardiology, NUHCS

Assistant Professor, Department of Medicine, Yong Loo Lin School of Medicine, NUS


Assistant Professor Chester Drum, M.D. Ph.D., is an assistant professor at the National University of Singapore, a consultant cardiologist at the National University Hospital and director of the Clinical Trial Innovation Lab at TLGM, A*STAR. He is a Singapore permanent resident and currently maintains both internal medicine and cardiology board certifications in the US and Singapore. Asst. Prof. Drum received an M.D. and Ph.D. from the University of Chicago. He was trained in internal medicine at the University of California, San Diego and as a cardiologist at the Brigham and Women’s Hospital (Harvard Medical School) in Boston. After receiving the Burroughs Wellcome Career Award for Medical Scientists, he then moved to Massachusetts Institute of Technology (MIT) where he was director of Translational Medicine for the regulatory innovation group, MIT-NEWDIGS. Asst. Prof. Drum has over 20 years of clinical experience in managed care, private, public and academic healthcare settings and holds multiple patents. In 2011, he was recruited to the National University of Singapore and has since received funding from the Singapore MIT Alliance for Research and Technology, National Medical Research Council, Biomedical Research Council, A*STAR and the Yong Loo Lin School of Medicine at the National University of Singapore.


Asst. Prof. Drum’s current research bridges the gap between basic biochemistry and clinical care. Using fundamental concepts in biochemistry and synthetic biology, the lab creates novel therapeutics for unmet clinical needs. Biochemical investigations of human cohorts often leverage mass spectroscopy to answer fundamental questions of disease mechanism and prognosis. Asst. Prof. Drum is currently the primary investigator on a multi-institutional, 3,000 person observational trial in Singapore which studies how personalized drug metabolism effects drug response. Recent publications include contributions to the journals Nature Communications, Journal of the American Heart Association, PNAS and Small in addition to featured editorial content in Science Translational Medicine


Recent Publications:

  1. Patra A, Ding T, Drum CL, Using extraordinary optical transmission to quantify cardiac biomarkers in human serum, J Vis Exp. 2017 Dec 13;(130). doi: 10.3791/55597
  2. Deshpande, S., Masurkar, N. D., Girish, V. M., Desai, M., Chakraborty, G., Chan, J. M., & Drum, C. L. (2017). Thermostable exoshells fold and stabilize recombinant proteins. Nature Communications, 8(1), 1442. doi:10.1038/s41467-017-01585-2 (IF = 13)

  3. Ohlson S, Kaur J, Raida M, Niss U, Bengala T, Drum CL, et al. Direct Analysis − No Sample Preparation − of Bioavailable Cortisol in Human Plasma by Weak Affinity Chromatography (WAC). Journal of Chromatography B. 2017 Jul. (IF = 4.17)

  4. Drum CL, Tan KY, Chan SP, Pakkiri LS, Chong PC, Liew OW, et. al, Thymosin beta-4 is elevated in women with heart failure with preserved ejection fraction,Journal of the American Heart Association. American Heart Association, Inc; 2017 Jun 1;6(6):e005586. (IF = 5.12) PMID: 28611096 / DOI: 10.1161/JAHA.117.005586

  5. Patra A, Ding T, Engudar G, Yi W, Dykas M, Liedberg B, Kah J, Venkatesan T, Drum CL. Component Specific Analysis of Plasma Protein Corona Formation On Gold Nanoparticles Using Multiplexed Surface Plasmon Resonance. Small. 2016 03-20;12(9):1174-82. doi: 10.1002/smll.201501603. (IF = 8.6)

  6. Garcia-Miralles M, Ooi J, Bardile CF, Tan LJ, George M, Drum CL, et al. Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease. Experimental Neurology. 2016 Jan 26;278:4–10. (5yr IF = 4.479, 2yr IF = 4.657)

  7. Halliwell B, Cheah IK, Drum CL. Ergothioneine, an adaptive antioxidant for the protection of injured tissues? A hypothesis. Biochem Biophys Res Commun. 2016 Jan 6.doi: 10.1016/j.bbrc.2015.12.124 (5yr IF = 2.392, 2yr IF = 2.371)

  8. Ding T, Hong M, Richards AM, It Wong Ten, Zhou X, Drum CL. Quantification of a Cardiac Biomarker in Human Serum Using Extraordinary Optical Transmission (EOT). PLoS ONE. 2015 Mar 16;10(3):e0120974. (IF = 3.02)

  9. Drum CL. System-level prescriptions for adaptive drug licensing. Science Translational Medicine. 2015 Mar 4;7(277):277ec36. 

  10. Chan JM, Wong KHK, Richards AM, Drum CL. Microengineering in cardiovascular research: new developments and translational applications. Cardiovascular Research. 2015 Feb 17.  (IF = 5.46) (editor’s choice)

  11. Drum CL. TRIPOD puts prediction models on a firmer footing. Science Translational Medicine. 2015 Jan 28;7(272):272ec14–4. 

  12. Drum CL. Watch your leftovers: Remnant cholesterol brings oversized risk to cardiovascular health. Science Translational Medicine. 2014 Dec 3;6(265):205. 

  13. Yu J, Tao D, Ng EX, Drum CL, Liu AQ, Chen C-H. Real-time measurement of thrombin generation using continuous droplet microfluidics. Biomicrofluidics. 2014 Sep;8(5):052108. 

  14. Drum CL. Long non-coding RNAs in myocardial infarction. Science Translational Medicine. 2014 Jul 30;6(247):131. 

  15. Eichler H-G, Oye K, Baird LG, Abadie E, Brown J, Drum CL, et al. Adaptive licensing: taking the next step in the evolution of drug approval. Clin Pharmacol Ther. 2012 Mar;91(3):426–37. 

  16. Chan JM, Rhee J-W, Drum CL, Bronson RT, Golomb G, Langer R, et al. In vivo prevention of arterial restenosis with paclitaxel-encapsulated targeted lipid-polymeric nanoparticles. Proc Natl Acad Sci USA. National Acad Sciences; 2011 Nov 29;108(48):19347–52. 

  17. Shen Y, Guo Q, Zhukovskaya NL, Drum CL, Bohm A, Tang W-J. Structure of anthrax edema factor-calmodulin-adenosine 5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site. Biochem Biophys Res Commun. 2004 Apr 30;317(2):309–14. 

  18. Drum CL, Yan S-Z, Bard J, Shen Y-Q, Lu D, Soelaiman S, et al. Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin. Nature. 2002 Jan 24;415(6870):396–402. 


For more publications, click here.


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