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Home > Our Doctors > Our Doctors > Department of Cardiology > Assistant Professor William Kok-Fai Kong

Assistant Professor William Kok-Fai Kong



Consultant Department of Cardiology, NUHCS

Assistant Professor Department of Medicine, Yong Loo Lin School of Medicine, NUS


Assistant Professor William Kok-Fai Kong graduated from the Auckland University, New Zealand with a Bachelor of Medicine and Bachelor of Surgery (MBChB) . He completed advanced specialist training in Cardiology in Christchurch Hospital and Wellington Hospital in New Zealand. He was admitted as a fellow of Royal Australasian College of Physician (FRACP) in Cardiology in 2011.


He obtained the Academic Medicine Development Award (AMDA) in 2014 to undergo subspecialty training in interventional echocardiography, structural heart disease/valvular heart disease in Leiden University Medical Centre in the Netherlands under the supervision of Dr Victoria Delgado and Professor Jeroen J Bax, the immediate past president of European Society of Cardiology (ESC). He is also undergoing PhD study at the Leiden University Medical Centre (LUMC) at Leiden, the Netherlands examining the epidemiology, clinical, genetics and imaging aspects of bicuspid aortic valve and aortopathy.


He was subsequently elected Fellow of the Royal College of Physicians (Edinburgh), Fellow of the European Society of Cardiology in 2017, and Fellow of the American College of Cardiology in 2018. He was appointed as Specialty Editor in Cardiology for Singapore Medical Journal since 2016.


Currently, he is running a weekly Valve Clinic to follow up patients with valvular heart disease and to provide transesopahgeal echocardiography and stress echocardiography services in NUH. He is also a member of the Heart Team providing echocardiographic assessment/support for transcatheter therapies for patients who deemed high risk for surgery. He chairs the Valve Round every fortnight and is actively involved in the management of patients with valvular heart diseases/structural heart disease.


Assistant Professor Kong has published as first author multiple times in some highest impact factor cardiology journals such as European Heart Journal, Journal of American College of Cardiology, Circulation: Cardiovascular Imaging and JAMA Cardiology . He is a reviewer for several international cardiology journals such as Circulation and Journal of American Society of Echocardiography (JASE).


He supervises research and clinical training for senior residents and clinical fellows from Singapore and overseas. Assistant Professor Kong is currently the primary investigator of a worldwide biggest multi-centre, 3,500 bicuspid aortic valve disease registry. He is also primary and co-investigators in a lot of multi-centre registries.



1. Working Group member of Valvular Heart Disease for European Society of Cardiology (ESC)  

2. Working Group member of Myocardial And Pericardial Disease for European Society of Cardiology (ESC)

3. Specialty Editor (Cardiology), Singapore Medical Journal

4. Assistant Professor, Yong Loo Lin Medical School, National University of Singapore

5. Visiting consultant, Ng Teng Fong General Hospital Singapore


Specialty Interest(s):

  • 3D/4D Transesophageal Echocardiography
  • Interventional Echocardiography
  • Bicuspid Aortic Valve and Aortopathy
  • Transcatheter Aortic Valve Replacement
  • MitraClip, Left atrial appendage closure



  • European Society of Cardiology congress 2015 in London - Best Poster Award
  • NUHS Quality Improvement Project / Rapid Improvement Event Awards - Merit Award Jan-April 2015
  • Transcatheter Cardiovascular Therapeutics Asia Pacific 2014 - Best Abstract Award (moderated poster category)
  • Transcatheter Cardiovascular Therapeutics Asia Pacific 2014 - Best Abstract Award (oral presentation category)
  • Academic Medicine Development Award (AMDA) in 2014


Selected Publications:

  1. Takotsubo hypertrophic obstructive cardiomyopathy and bicuspid valvulopathy: implication of multiple imaging modalities. Kong WK, Loh PH, Teo L, Ong CC, Wong RC. Eur Heart J. 2018 Oct 17. doi: 10.1093/eurheartj/ehy673. [Epub ahead of print]

  2. Paravalvular root abscess with mycotic pseudoaneurysm. Kong WKF, Choong CC, Sule JA, Poh KK, Kofidis T. Eur Heart J. 2018 Nov 1;39(41):3751-3752. doi: 10.1093/eurheartj/ehy416.

  3. Atretic aortic valvular cusp causing severe aortic regurgitation. Wong RC, Yip JWL, Tay ELW, Kong WKF. Eur Heart J Cardiovasc Imaging. 2018 Sep 1;19(9):1072-1073. doi: 10.1093/ehjci/jey074.

  4. Transcatheter Aortic Valve Replacement in Pure Native Aortic Valve Regurgitation. Yoon SH, Schmidt T, Bleiziffer S, Schofer N, Fiorina C, Munoz-Garcia AJ, Yzeiraj E, Amat-Santos IJ, Tchetche D, Jung C, Fujita B, Mangieri A, Deutsch MA, Ubben T, Deuschl F, Kuwata S, De Biase C, Williams T, Dhoble A, Kim WK, Ferrari E, Barbanti M, Vollema EM, Miceli A, Giannini C, Attizzani GF, Kong WKF, Gutierrez-Ibanes E, Jimenez Diaz VA, Wijeysundera HC, Kaneko H, Chakravarty T, Makar M, Sievert H, Hengstenberg C, Prendergast BD, Vincent F, Abdel-Wahab M, Nombela-Franco L, Silaschi M, Tarantini G, Butter C, Ensminger SM, Hildick-Smith D, Petronio AS, Yin WH, De Marco F, Testa L, Van Mieghem NM, Whisenant BK, Kuck KH, Colombo A, Kar S, Moris C, Delgado V, Maisano F, Nietlispach F, Mack MJ, Schofer J, Schaefer U, Bax JJ, Frerker C, Latib A, Makkar RR. J Am Coll Cardiol. 2017 Dec 5;70(22):2752-2763. doi: 10.1016/j.jacc.2017.10.006

  5. Double Orifice Barlow’s Mitral Valve. Zhengfeng Chen, William KF Kong, Edgar LW Tay, Fredrik Petersson, Kian Keong Poh Eur Heart J. 2017 Dec 9. doi: 10.1093/eurheartj/ehx671.

  6. Inter-ethnic differences in valve morphology, valvular dysfunction, and aortopathy between Asian and European patients with bicuspid aortic valve. Kong WKF, Regeer MV, Poh KK, Yip JW, van Rosendael PJ, Yeo TC, Tay E, Kamperidis V, van der Velde ET, Mertens B, Ajmone Marsan N, Delgado V, Bax JJ. Eur Heart J. 2017 Oct 6. doi: 10.1093/eurheartj/ehx562.

  7. Bicuspid Aortic Valve: What to Image in Patients Considered for Transcatheter Aortic Valve Replacement?Kong WKF, Delgado V, Bax JJ. Circ Cardiovasc Imaging. 2017 Sep;10(9). pii: e005987. doi: 10.1161/CIRCIMAGING.117.005987. Review.

  8. Successful Transcatheter Aortic Valve Replacement for Severe Aortic Valve Regurgitation Following a David I Valve-Sparing Procedure. Tay EL, Kong WK, Yip JW, Low TT, Hon JK. JACC Cardiovasc Interv. 2017 Jun 12;10(11):e101-e103. doi: 10.1016/j.jcin.2017.03.035. Epub 2017 May 17.

  9. Bicuspid Aortopathy. Delgado V, Kong WKF, Bax JJ. JAMA Cardiol. 2017 Sep 1;2(9):1047-1048. doi: 10.1001/jamacardio.2017.1272.

  10. Transcatheter aortic valve thrombosis: the relation between hypo-attenuated leaflet thickening, abnormal valve haemodynamics, and stroke. Kong WKF, Vollema EM, Katsanos S, Kamperidis V, van Rosendael PJ, van der Kley F, de Weger A, Ajmone Marsan N, Delgado V, Bax JJ. Eur Heart J. 2017 Apr 21;38(16):1207-1217. doi: 10.1093/eurheartj/ehx031

  11. Outcomes in Transcatheter Aortic Valve Replacement for Bicuspid Versus Tricuspid Aortic Valve Stenosis. Yoon SH, Bleiziffer S, De Backer O, Delgado V, Arai T, Ziegelmueller J, Barbanti M, Sharma R, Perlman GY, Khalique OK, Holy EW, Saraf S, Deuschl F, Fujita B, Ruile P, Neumann FJ, Pache G, Takahashi M, Kaneko H, Schmidt T, Ohno Y, Schofer N, Kong WKF, Tay E, Sugiyama D, Kawamori H, Maeno Y, Abramowitz Y, Chakravarty T, Nakamura M, Kuwata S, Yong G, Kao HL, Lee M, Kim HS, Modine T, Wong SC, Bedgoni F, Testa L, Teiger E, Butter C, Ensminger SM, Schaefer U, Dvir D, Blanke P, Leipsic J, Nietlispach F, Abdel-Wahab M, Chevalier B, Tamburino C, Hildick-Smith D, Whisenant BK, Park SJ, Colombo A, Latib A, Kodali SK, Bax JJ, Søndergaard L, Webb JG, Lefèvre T, Leon MB, Makkar R. J Am Coll Cardiol. 2017 May 30;69(21):2579-2589. doi: 10.1016/j.jacc.2017.03.017. Epub 2017 Mar 18

  12. Mitral valve repair for secondary mitral regurgitation in non-ischaemic dilated cardiomyopathy is associated with left ventricular reverse remodelling and increase of forward flow. Kamperidis V, van Wijngaarden SE, van Rosendael PJ, Kong WK, Regeer MV, van der Kley F, Sianos G, Ajmone Marsan N, Bax JJ, Delgado V. Eur Heart J Cardiovasc Imaging. 2017 Feb 23. doi: 10.1093/ehjci/jex011.

  13. Sex Differences in Phenotypes of Bicuspid Aortic Valve and Aortopathy: Insights From a Large Multicenter, International Registry. Kong WK, Regeer MV, Ng AC, McCormack L, Poh KK, Yeo TC, Shanks M, Parent S, Enache R, Popescu BA, Yip JW, Ma L, Kamperidis V, van der Velde ET, Mertens B, Ajmone Marsan N, Delgado V, Bax JJ. Circ Cardiovasc Imaging. 2017 Mar;10(3). pii: e005155. doi: 10.1161/CIRCIMAGING.116.005155.

  14. Integrated imaging of echocardiography and computed tomography to grade mitral regurgitation severity in patients undergoing transcatheter aortic valve implantation. van Rosendael PJ, van Wijngaarden SE, Kamperidis V, Kong WKF, Leung M, Ajmone Marsan N, Delgado V, Bax JJ. Eur Heart J. 2017 Jul 21;38(28):2221-2226. doi: 10.1093/eurheartj/ehw612.

  15. Prognostic Implications of Raphe in Bicuspid Aortic Valve Anatomy. Kong WK, Delgado V, Poh KK, Regeer MV, Ng AC, McCormack L, Yeo TC, Shanks M, Parent S, Enache R, Popescu BA, Liang M, Yip JW, Ma LC, Kamperidis V, van Rosendael PJ, van der Velde ET, Ajmone Marsan N, Bax JJ. JAMA Cardiol. 2017 Mar 1;2(3):285-292. doi: 10.1001/jamacardio.2016.5228

  16. Computed tomography for planning transcatheter tricuspid valve therapy. van Rosendael PJ, Kamperidis V, Kong WK, van Rosendael AR, van der Kley F, Ajmone Marsan N, Delgado V, Bax JJ. Eur Heart J. 2017 Mar 1;38(9):665-674. doi: 10.1093/eurheartj/ehw499

  17. Transcatheter Aortic Valve Replacement With Early- and New-Generation Devices in Bicuspid Aortic Valve Stenosis. Yoon SH, Lefèvre T, Ahn JM, Perlman GY, Dvir D, Latib A, Barbanti M, Deuschl F, De Backer O, Blanke P, Modine T, Pache G, Neumann FJ, Ruile P, Arai T, Ohno Y, Kaneko H, Tay E, Schofer N, Holy EW, Luk NHV, Yong G, Lu Q, Kong WKF, Hon J, Kao HL, Lee M, Yin WH, Park DW, Kang SJ, Lee SW, Kim YH, Lee CW, Park SW, Kim HS, Butter C, Khalique OK, Schaefer U, Nietlispach F, Kodali SK, Leon MB, Ye J, Chevalier B, Leipsic J, Delgado V, Bax JJ, Tamburino C, Colombo A, Søndergaard L, Webb JG, Park SJ. J Am Coll Cardiol. 2016 Sep 13;68(11):1195-1205. doi: 10.1016/j.jacc.2016.06.041.

  18. Prevalence, clinical and echocardiographic characteristics of various flow and gradient patterns in mild or moderate aortic stenosis with normal left ventricular ejection fraction. Tan YQ, Ngiam JN, Kong WK, Yeo TC, Poh KK. Int J Cardiol. 2016 Oct 15;221:1107-15. doi: 10.1016/j.ijcard.2016.07.055. Epub 2016 Jul 5

  19. Transcatheter aortic valve implantation: from revolution to evolution. Tay EL, Poh KK, Yip JW, Kong WK. Singapore Med J. 2016 Jul;57(7):406-7. doi: 10.11622/smedj.2016122.

  20. Impact of Different Iterations of Devices and Degree of Aortic Valve Calcium on Paravalvular Regurgitation After Transcatheter Aortic Valve Implantation. Kong WK, van Rosendael PJ, van der Kley F, de Weger A, Kamperidis V, Regeer MV, Marsan NA, Bax JJ, Delgado V. Am J Cardiol. 2016 Aug 15;118(4):567-71. doi: 10.1016/j.amjcard.2016.05.053. Epub 2016 May 29

  21. Anaemia in patients with aortic stenosis: influence on long-term prognosis. Ng AC, Kong WK, Kamperidis V, Bertini M, Antoni ML, Leung DY, Marsan NA, Delgado V, Bax JJ. Eur J Heart Fail. 2015 Oct;17(10):1042-9. doi: 10.1002/ejhf.297. Epub 2015 Jun 4


For more publications, click here.

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