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Home > Our Doctors > Our Doctors > Department of Cardiac, Thoracic and Vascular Surgery > Associate Professor Theodoros Kofidis

Associate Professor Theodoros Kofidis



Head and Senior Consultant Department of Cardiac, Thoracic and Vascular Surgery, NUHCS
Chairman Initiative for Research and Innovation of Surgery (IRIS)
Associate Professor Department of Surgery, Yong Loo Lin School of Medicine, NUS


Professor Theodoros Kofidis is the Head of Department of Cardiac, Thoracic and Vascular Surgery, Senior Consultant Cardiothoracic Surgeon and a pioneer in Minimally Invasive Heart Surgery. He is also an Associate Professor with the Department of Surgery, Yong Loo Lin School of Medicine. His vision is to help thousands of patients in Singapore and around the globe through cutting edge, less traumatic heart surgery. He promotes and offers a wide range of traditional and less invasive, small-incision and keyhole access procedures for bypass and heart valve surgery. He has a wide spectrum of expertise in Less Invasive and Hybrid Heart Surgery, Heart Failure Surgery and Off-pump procedures.  He has introduced numerous new technologies of his field in the region, as well as launched new types of less invasive surgery, now featuring on professional forums and the Internet across the globe. He is invited around the world to train doctors and nurses in Minimally Invasive Heart Surgery as well as to hold workshops. He has established a Unique Centre of Excellence in Minimally Invasive Heart Surgery with the support from NUHCS/NUHS Leadership and industries in the field.


He has trained in some of the world’s leading institutions (Rochester, NY/Texas heart, Houston/Hannover Germany, Stanford, CA, USA). He is decorated with numerous international awards and carries various offices and commitments internationally. As an academic teacher, proctor and Consultant in the field-related industry, he is holding events and workshops in various countries around the world. He is Editor and Reviewer for various other scientific bodies. Professor Kofidis is a Fellow of Royal College of Surgeons of Edinburgh, and was also elected member of the prestigious American Association of Thoracic Surgery.


Prof Kofidis has a profound contribution to heart-related research. His innovations, discoveries and his patents in Heart Surgery, published in more than 120 articles in international journals, including Nature, have earned him prestigious international awards, and the honor of invited lecturer at Bill Gates Research Centre, the American Medical Association, and the NIH and FDA in the USA. He has founded a new initiative to promote research and innovative technology in surgery (I.R.I.S.), which helped more than 150 students and postgraduates start their Academic career. He has invented new surgical tools and currently develops the “SingValve”, and has founded the company “Kardia, Pte, Ltd” to produce such technology in Singapore.


Prof Theodoros Kofidis is married to Persephone, an architect and they have a daughter, Danai. His hobbies include aviation (piloting planes), photography, working-out and reading.


Specialty Interest(s):


  • Coronary Artery Bypass Grafting
  • Off-Pump Coronary artery Bypass Grafting (no Heart-Lung Machine)
  • Totally Arterial Bypass Grafting
  • Minimal Invasive Coronary Artery Grafting
  • Minimal invasive vein harvest
  • Redo CABG Surgery
  • Aortic Valve Replacement (+ minimally invasive)
  • Aortic Valve Repair (+ minimally invasive)
  • Mitral Valve Replacement (+ minimally invasive)
  • Mitral Valve Repair (+ minimally invasive)
  • Heart Rhythm Surgery (Atrial Fibrillation and others, also minimally invasive)
  • Tricuspid and Pulmonary Valve Surgery
  • Aortic aneurysm and dissections of the thoracic aorta
  • All cardiac emergencies
  • Cardiac Tumors and clots (Pulmonary embolism)
  • Heart failure Surgery, including Assist device implantation, ECMO, Transplantation
  • Left ventricular Reconstructive procedures
  • Minimal Invasive Cardiac Surgery
  • Lung Surgery: VATS (Video-Assisted, endoscopic) - Pneumothorax treatment, Wedge 
  • Lobectomies
  • Stem Cell Therapies
  • Robotic Cardiac Surgery


Specializes in Diseases and Conditions:


  • Coronary Heart Disease
  • Valvular Heart Disease
  • Heart Failure
  • Aortic Aneurysm


Selected Publications


1. Biohybrid Cardiac ECM-Based Hydrogels Improve Long Term Cardiac Function Post Myocardial Infarction. Efraim Y, Sarig H, Cohen Anavy N1, Sarig U, de Berardinis E, Chaw SY, Krishnamoorthi M, Kalifa J, Bogireddi H, Vu Duc T, Kofidis T, Baruch L, Y C Boey F, Venkatraman SS, Machluf M. Acta Biomater. 2016 Dec 9. pii: S1742-7061(16)30683-3. doi: 10.1016/j.actbio.2016.12.015. [Epub ahead of print]  PMID: 27956366 (IF: 6.008)


2. Dual delivery of VEGF and ANG-1 in ischemic hearts using an injectable hydrogel. Jalil Rufaihah A, Azizah Johari N, Ramanujam Vaibavi S, Plotkin M, Thi Di Thien D, Kofidis T, Seliktar D. Acta Biomater. 2016 Oct 15. pii: S1742-7061(16)30540-2. doi: 10.1016/j.actbio.2016.10.013. PMID: 27756647 (IF: 6.008)


3. Natural myocardial ECM patch drives cardiac progenitor based restoration even after scarring. Sarig U, Sarig H, de-Berardinis E, Chaw SY, Nguyen EB, Ramanujam VS, Thang VD, Al-Haddawi M, Liao S, Seliktar D, Kofidis T, Boey FY, Venkatraman SS, Machluf M. Acta Biomater. 2016 Oct 15;44:209-20. doi: 10.1016/j.actbio.2016.08.031. Epub 2016 Aug 18. PMID: 27545814 (IF: 6.008)


4. A Score for Predicting Acute Kidney Injury After Coronary Artery Bypass Graft Surgery in an Asian Population. Mithiran H, Kunnath Bonney G, Bose S, Subramanian S, Zhe Yan ZN, Zong En SY, Papadimas E, Chauhan I, MacLaren G, Kofidis T. J Cardiothorac Vasc Anesth. 2016 Oct;30(5):1296-301. doi: 10.1053/j.jvca.2016.03.135. Epub 2016 Mar 17. PMID: 27474335 (IF: 1.519)


5. Sleep apnoea is a risk factor for acute kidney injury after coronary artery bypass grafting. Kua J, Zhao LP, Kofidis T, Chan SP, Yeo TC, Tan HC, Lee CH. Eur J Cardiothorac Surg. 2016 Apr;49(4):1188-94. doi: 10.1093/ejcts/ezv382. Epub 2015 Nov 17. PMID: 26582346 (IF: 2.803)


6. Sleep apnea is associated with new-onset atrial fibrillation after coronary artery bypass grafting. Zhao LP, Kofidis T, Lim TW, Chan SP, Ong TH, Tan HC, Lee CH. J Crit Care. 2015 Dec;30(6):1418.e1-5. doi: 10.1016/j.jcrc.2015.07.002. Epub 2015 Jul 9. PMID: 26235653 (IF: 2.445)


7. Sleep apnoea and unscheduled re-admission in patients undergoing coronary artery bypass surgery. Zhao LP, Kofidis T, Chan SP, Ong TH, Yeo TC, Tan HC1, Lee CH. Atherosclerosis. 2015 Sep;242(1):128-34. doi: 10.1016/j.atherosclerosis.2015.07.006. Epub 2015 Jul 10. PMID: 26188535 (IF: 3.942)


8. Unravelling the Proteome of Degenerative Human Mitral Valves. Tan HT, Lim TK, Richards AM, Kofidis T, Teoh KL, Ling LH, Chung MC. Proteomics. 2015 Sep;15(17):2934-44. doi: 10.1002/pmic.201500040. Epub 2015 Jun 8. PMID: 25914152 (IF: 4.079)


9. An autologous platelet-rich plasma hydrogel compound restores left ventricular structure, function and ameliorates adverse remodeling in a minimally invasive large animal myocardial restoration model: a translational approach: Vu and Pal "Myocardial Repair: PRP, Hydrogel and Supplements". Vu TD, Pal SN, Ti LK, Martinez EC, Rufaihah AJ, Ling LH, Lee CN, Richards AM, Kofidis T. Biomaterials. 2015 Mar;45:27-35. doi: 10.1016/j.biomaterials.2014.12.013. Epub 2015 Jan 13. PMID: 25662492 (IF: 8.387)


10. Coaxial projection profilometry based on speckle and fringe projection.  Cong Liu, Lujie Chen, Xiaoyuan He, Vu Duc Thang, Theodoro Kofidis. Optics Communications 341 (2015) 228-236. WoS & Scopus (IF: 1.48)


11. Sutureless aortic valve implantation: first experience in Asia. Chang G, Vu dT, Teoh KL, Ti LK, Kofidis T. Singapore Med J. 2014 Nov;55(11):598-600. PMID: 25631972 (IF: 0.573)


12. Feasibility of transapical cardioscopic surgery in a pig model. Kofidis T, Duc Vu T, Pal SN, Vaibavi SR, Chang G, Chua YC, Ti LK, Lee CN. J Card Surg. 2015 Apr;30(4):355-9. doi: 10.1111/jocs.12419. PMID: 25099949 (IF: 0.783)


13. Fiber optic projection-imaging system for shape measurement in confined space. Chen L, Bavigadda V, Kofidis T, Howe RD. Scientific World Journal. 2014 Feb 10;2014:206569. doi: 10.1155/2014/206569. eCollection 2014. PMID: 24688368 (IF:0)


14. Is continuation of antiplatelets until coronary artery bypass safe in Asians? Vu TD, Zaw MH, Chang G, Hu SL, Tay CW, Ng CW, Chia DK, Lee CN, Kofidis T. Asian Cardiovasc Thorac Ann. 2014 Oct;22(8):909-18. doi: 10.1177/0218492314521421. Epub 2014 Jan 27. PMID: 24585288 (IF: 0)


15. Influence of Prosthesis Type on Long-Term Survival after Re-replacement of Aortic Valve Prosthesis. Akhyari P, Lichtenberg A, Hartmann A, Ismail I, Hiroyuki K, Minol JP, Kofidis T, Klima U, Karck M, Haverich A. Heart Surg Forum. 2013 Dec 1;16(6):E298-302. doi: 10.1532/HSF98.20111167. PMID: 24370796 (IF: 0.343)


16. The effect of matrix stiffness of injectable hydrogels on the preservation of cardiac function after a heart attack. Plotkin M, Vaibavi SR, Rufaihah AJ, Nithya V, Wang J, Shachaf Y, Kofidis T, Seliktar D. Biomaterials. 2014 Feb;35(5):1429-38. doi: 10.1016/j.biomaterials.2013.10.058. Epub 2013 Nov 21.PMID: 24268664 (IF: 8.387)


17. Enhanced infarct stabilization and neovascularization mediated by VEGF-loaded PEGylated fibrinogen hydrogel in a rodent myocardial infarction model. Rufaihah AJ, Vaibavi SR, Plotkin M, Shen J, Nithya V, Wang J, Seliktar D, Kofidis T. Biomaterials. 2013 Nov;34(33):8195-202. doi: 10.1016/j.biomaterials.2013.07.031. Epub 2013 Jul 24. PMID: 23891519 (IF: 8.387)


18. Grafts Enriched with Subamnion-Cord-lining Mesenchymal Stem Cell Angiogenic Spheroids Induce Post-Ischemic Myocardial Re-vascularization and Preserve Cardiac Function in Failing Rat Hearts. Martinez EC, Vu DT, Wang J, Lilyanna S, Ling LH, Gan SU, Tan AL, Phan TT, Lee CN, Kofidis T. Stem Cells Dev. 2013 Dec 1;22(23):3087-99. doi: 10.1089/scd.2013.0119. Epub 2013 Aug 31. PMID: 23869939 (IF: 3.777)


19. Cord Lining-Mesenchymal Stem Cells Graft Supplemented with an Omental Flap Induces Myocardial Revascularization and Ameliorates Cardiac Dysfunction in a Rat Model of Chronic Ischemic Heart Failure. Lilyanna S, Martinez EC, Vu TD, Ling LH, Gan SU, Tan AL, Phan TT, Kofidis T. Tissue Eng Part A. 2013 Jun;19(11-12):1303-15. doi: 10.1089/ten.tea.2012.0407. Epub 2013 Feb 28. PMID: 23448654 (IF: 3.892)


20. Novel sutureless mitral valve implantation method involving a bayonet insertion and release mechanism: A proof of concept study in pigs. Vu DT, Ti LK, Ong LC, Neo PH, Lee CN, Kofidis T. J Thorac Cardiovasc Surg. 2012 Apr;143(4):985-8. doi: 10.1016/j.jtcvs.2012.01.037. Epub 2012 Feb 11. PMID: 22329979 (IF: 3.494)


For more publications, read here.




2000 Award for the best oral presentation of the Onassis Institute at the International Congress of Cardiothoracic Surgery, Onassis Heart Center, Athens, Greece.
2001 Award of the European Transplant Society for the best scientific work, Basel, Switzerland. 2002  The German Research Society Grant Award.
2002 The German Research Society Grant Award.
2004 The Rockefeller Brothers Fund/Culpeper Bioscience Award, NY, USA.
2005 Funding Award of the Brauckmann Foundation, Hannover, Germany.
2006 The Lillehei-Caster Award of the European Society of Cardiothoracic Surgery, Stockholm  Sweden.
2012 The Lifetime achievement/contribution Award by the Hellenic Cardiology Society.
2014 The MOH AMDA Award.
2015 The Fellowship of the Royal College of Surgeons of Edinburgh, without examination.


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