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Home > Our Doctors > Our Doctors > Department of Cardiac, Thoracic and Vascular Surgery > Associate Professor Theodoros Kofidis

Associate Professor Theodoros Kofidis



Head and Senior Consultant Department of Cardiac, Thoracic and Vascular Surgery, NUHCS
Chairman Initiative for Research and Innovation of Surgery (IRIS)
Associate Professor Department of Surgery, Yong Loo Lin School of Medicine, NUS


Professor Theodoros Kofidis is the Head of Department of Cardiac, Thoracic and Vascular Surgery, Senior Consultant Cardiothoracic Surgeon and a pioneer in Minimally Invasive Heart Surgery. He is also an Associate Professor with the Department of Surgery, Yong Loo Lin School of Medicine. His vision is to help thousands of patients in Singapore and around the globe through cutting edge, less traumatic heart surgery. He promotes and offers a wide range of traditional and less invasive, small-incision and keyhole access procedures for bypass and heart valve surgery. He has a wide spectrum of expertise in Less Invasive and Hybrid Heart Surgery, Heart Failure Surgery and Off-pump procedures.  He has introduced numerous new technologies of his field in the region, as well as launched new types of less invasive surgery, now featuring on professional forums and the Internet across the globe. He is invited around the world to train doctors and nurses in Minimally Invasive Heart Surgery as well as to hold workshops. He has established a Unique Centre of Excellence in Minimally Invasive Heart Surgery with the support from NUHCS/NUHS Leadership and industries in the field.


He has trained in some of the world’s leading institutions (Rochester, NY/Texas heart, Houston/Hannover Germany, Stanford, CA, USA). He is decorated with numerous international awards and carries various offices and commitments internationally. As an academic teacher, proctor and Consultant in the field-related industry, he is holding events and workshops in various countries around the world. He is Editor and Reviewer for various other scientific bodies. Professor Kofidis is a Fellow of Royal College of Surgeons of Edinburgh, and was also elected member of the prestigious American Association of Thoracic Surgery.


A/Prof. Kofidis has a profound contribution to heart-related research. His innovations, discoveries and his patents in Heart Surgery, published in more than 120 articles in international journals, including Nature, have earned him prestigious international awards, and the honor of invited lecturer at Bill Gates Research Centre, the American Medical Association, and the NIH and FDA in the USA. He has founded a new initiative to promote research and innovative technology in surgery (I.R.I.S.), which helped more than 150 students and postgraduates start their Academic career. He has invented new surgical tools and currently develops the “SingValve”, and has founded the company “Kardia, Pte, Ltd” to produce such technology in Singapore.


Professor Theo Kofidis lives in Singapore with his wife Persephone and daughter Danai, and is also a passionate pilot and photographer.


Specialty Interest(s):


  • Coronary Artery Bypass Grafting
  • Off-Pump Coronary artery Bypass Grafting (no Heart-Lung Machine)
  • Totally Arterial Bypass Grafting
  • Minimal Invasive Coronary Artery Grafting
  • Minimal invasive vein harvest
  • Redo CABG Surgery
  • Aortic Valve Replacement (+ minimally invasive)
  • Aortic Valve Repair (+ minimally invasive)
  • Mitral Valve Replacement (+ minimally invasive)
  • Mitral Valve Repair (+ minimally invasive)
  • Heart Rhythm Surgery (Atrial Fibrillation and others, also minimally invasive)
  • Tricuspid and Pulmonary Valve Surgery
  • Aortic aneurysm and dissections of the thoracic aorta
  • All cardiac emergencies
  • Cardiac Tumors and clots (Pulmonary embolism)
  • Heart failure Surgery, including Assist device implantation, ECMO, Transplantation
  • Left ventricular Reconstructive procedures
  • Minimal Invasive Cardiac Surgery
  • Lung Surgery: VATS (Video-Assisted, endoscopic) - Pneumothorax treatment, Wedge 
  • Lobectomies
  • Stem Cell Therapies
  • Robotic Cardiac Surgery


Specializes in Diseases and Conditions:


  • Coronary Heart Disease
  • Valvular Heart Disease
  • Heart Failure
  • Aortic Aneurysm


Selected Publications


Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL, Robbins RC. Nature. 2004 Apr; 428(6983): 668-73.


Novel, Injectable Bioartificial Tissue facilitates Targeted, Less Invasive, Large-Scale Tissue Restoration on the Beating Heart following Myocardial Injury. Kofidis T, Lebl DR, Martinez EC, Hoyt G, Tanaka M, Robbins RC. Circulation. 2005;112(9 Suppl):I173-7.


Stimulation of paracrine pathways with growth factors enhances embryonic stem cell engraftment and host-specific differentiation in the heart after ischemic myocardial injury. Kofidis T, de Bruin JL, Yamane T, Tanaka M, Lebl DR, Swijnenburg RJ, Weissman IL, Robbins RC. Circulation. 2005; May 111(19):2486-93.


Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium. Swijnenburg RJ, Tanaka M, Vogel H, Baker J, Kofidis T, Gunawan F, Lebl DR, Caffarelli AD, de Bruin JL, Fedoseyeva EV, Robbins RC. Circulation. 2005;112, (9 Suppl):I166-72.


Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts. Tanaka M, Terry RD, Mokhtari GK, Inagaki K, Koyanagi T, Kofidis T, Mochly-Rosen D, Robbins RC.  Circulation. 2004 Sep;110(11 Suppl 1):II194-9.


For more publications, read here.




2000 Award for the best oral presentation of the Onassis Institute at the International Congress of Cardiothoracic Surgery, Onassis Heart Center, Athens, Greece.
2001 Award of the European Transplant Society for the best scientific work, Basel, Switzerland. 2002  The German Research Society Grant Award.
2002 The German Research Society Grant Award
2004 The Rockefeller Brothers Fund/Culpeper Bioscience Award, NY, USA.
2005 Funding Award of the Brauckmann Foundation, Hannover, Germany.
2006 The Lillehei-Caster Award of the European Society of Cardiothoracic Surgery, Stockholm  Sweden.


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